Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors
To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocell...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
Hepatology
Year: 2012, Jahrgang: 56, Heft: 5, Pages: 1817-1827 |
| ISSN: | 1527-3350 |
| DOI: | 10.1002/hep.25870 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1002/hep.25870 Verlag, kostenfrei, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.25870 
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| Verfasserangaben: | Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich |
| Zusammenfassung: | To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs from 63 HCCs and 10 healthy control livers were analyzed for the methylation status of more than 14,000 genes. |
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| Beschreibung: | First published: 11 June 2012 Gesehen am 15.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1527-3350 |
| DOI: | 10.1002/hep.25870 |