Consensus report on the radiological management of patients with gastrointestinal stromal tumours (GIST): recommendations of the German GIST Imaging Working Group
The aim was to reach consensus in imaging for staging and follow-up as well as for therapy response assessment in patients with gastrointestinal stromal tumours (GIST). The German GIST Imaging Working Group was formed by 9 radiologists engaged in assessing patients with GIST treated with targeted th...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Cancer imaging
Year: 2012, Volume: 12, Pages: 126-135 |
| ISSN: | 1470-7330 |
| DOI: | 10.1102/1470-7330.2012.0013 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1102/1470-7330.2012.0013 Verlag, kostenfrei, Volltext: https://ncbi.nlm.nih.gov/pmc/articles/PMC3362866 
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| Author Notes: | Janine Kalkmann, Martin Zeile, Gerald Antoch, Frank Berger, Stefan Diederich, Dietmar Dinter, Christian Fink, Rolf Janka, Jörg Stattaus |
| Summary: | The aim was to reach consensus in imaging for staging and follow-up as well as for therapy response assessment in patients with gastrointestinal stromal tumours (GIST). The German GIST Imaging Working Group was formed by 9 radiologists engaged in assessing patients with GIST treated with targeted therapy. The following topics were discussed: indication and optimal acquisition techniques of computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET)/CT; tumour response assessment considering response criteria and measurement techniques on CT, MRI and PET/CT; result interpretation; staging interval and pitfalls. Contrast-enhanced CT is the standard method for GIST imaging. MRI is the method of choice in case of liver-specific questions or contraindications to CT. PET/CT should be used for early response assessment or inconclusive results on morphologic imaging. All imaging techniques should be standardized allowing a reliable response assessment. Response has to be assessed with respect to lesion size, lesion density and appearance of new lesions. A critical issue is pseudoprogression due to myxoid degeneration or intratumoural haemorrhage. The management of patients with GIST receiving a targeted therapy requires a standardized algorithm for imaging and an appropriate response assessment with respect to changes in lesion size and density. |
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| Item Description: | Published online 2012 May 7 Gesehen am 18.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1470-7330 |
| DOI: | 10.1102/1470-7330.2012.0013 |