Post-translational modifications of centromeric chromatin
Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromati...
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| Main Authors: | , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
2017
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| In: |
Centromeres and Kinetochores
Year: 2017, Pages: 213-231 |
| DOI: | 10.1007/978-3-319-58592-5_9 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/978-3-319-58592-5_9 Verlag, Volltext: https://link.springer.com/chapter/10.1007/978-3-319-58592-5_9 
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| Author Notes: | Ana García del Arco, Sylvia Erhardt |
| Summary: | Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone modifications. The composition of centromeric chromatin is significantly different from other chromatin structures and mainly defined by the presence of the histone H3-variant CENP-A. Here we summarize the composition of centromeric chromatin and what we know about its differential regulation by post-translational modifications. |
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| Item Description: | First online: 25 August 2017 Gesehen am 19.06.2018 |
| Physical Description: | Online Resource |
| ISBN: | 9783319585925 |
| DOI: | 10.1007/978-3-319-58592-5_9 |