Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year
Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
|
| In: |
Clinical biochemistry
Year: 2017, Volume: 50, Issue: 16, Pages: 942-946 |
| ISSN: | 1873-2933 |
| DOI: | 10.1016/j.clinbiochem.2017.05.017 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.clinbiochem.2017.05.017 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0009912017302515 
|
| Author Notes: | Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1576537668 | ||
| 003 | DE-627 | ||
| 005 | 20220814170110.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180619s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clinbiochem.2017.05.017 |2 doi | |
| 035 | |a (DE-627)1576537668 | ||
| 035 | |a (DE-576)506537668 | ||
| 035 | |a (DE-599)BSZ506537668 | ||
| 035 | |a (OCoLC)1341011990 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Graf, Mirja E. |e VerfasserIn |0 (DE-588)1161444343 |0 (DE-627)1025076109 |0 (DE-576)506537730 |4 aut | |
| 245 | 1 | 0 | |a Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year |c Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn |
| 264 | 1 | |c 2017 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.06.2018 | ||
| 500 | |a Available online 29 May 2017 | ||
| 520 | |a Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be used as reliable biomarkers of platelet activation in epidemiological studies. Methods: We measured circulating P-Selectin, TM, TPO and GPIIb/IIIa by immunoassays in two blood samples of 78 participants of the EPIC Heidelberg study (47-80years, 50% female) that were collected one year apart. Biological reproducibility of biomarker levels over time and associations with routine biochemistry parameters were assessed by Spearman's correlation coefficients. Results: Statistical analyses revealed good reproducibility over one year for two of the analyzed markers, with Spearman coefficients of ρ=0.80 (P-Selectin) and ρ=0.73 (TPO) and reasonable reproducibility for TM (ρ=0.63) and GPIIb/IIIa (ρ=0.51). Levels of P-Selectin, TM, TPO and GPIIb/IIIa were not significantly associated with routine biochemistry parameters, such as glucose, HbA1c, LDL, HDL, Triglycerides and CRP. Conclusions: Our findings suggest that a single assessment of P-Selectin, TM, TPO and GPIIb/IIIa at baseline in prospective epidemiological studies is appropriate to investigate associations between platelet activation and risks of chronic diseases. | ||
| 650 | 4 | |a Biological reproducibility | |
| 650 | 4 | |a Glycoprotein IIb/IIIa | |
| 650 | 4 | |a Intra-individual variation | |
| 650 | 4 | |a P-Selectin | |
| 650 | 4 | |a Thrombomodulin | |
| 650 | 4 | |a Thrombopoietin | |
| 700 | 1 | |a Sookthai, Disorn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Johnson, Theron S. |d 1972- |e VerfasserIn |0 (DE-588)13177526X |0 (DE-627)513947442 |0 (DE-576)298736012 |4 aut | |
| 700 | 1 | |a Schübel, Ruth |d 1988- |e VerfasserIn |0 (DE-588)1143136152 |0 (DE-627)1002510228 |0 (DE-576)494927119 |4 aut | |
| 700 | 1 | |a Katzke, Verena |d 1981- |e VerfasserIn |0 (DE-588)1025371658 |0 (DE-627)722176163 |0 (DE-576)370276302 |4 aut | |
| 700 | 1 | |a Bugert, Peter |d 1964- |e VerfasserIn |0 (DE-588)1025332342 |0 (DE-627)722074018 |0 (DE-576)370212169 |4 aut | |
| 700 | 1 | |a Hoffmeister, Michael |d 1973- |e VerfasserIn |0 (DE-588)134103726 |0 (DE-627)560880820 |0 (DE-576)277089565 |4 aut | |
| 700 | 1 | |a Kaaks, Rudolf |d 1960- |e VerfasserIn |0 (DE-588)172809223 |0 (DE-627)697739562 |0 (DE-576)133665518 |4 aut | |
| 700 | 1 | |a Kühn, Tilman |d 1979- |e VerfasserIn |0 (DE-588)1059123908 |0 (DE-627)798013915 |0 (DE-576)415142644 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical biochemistry |d Amsterdam [u.a.] : Elsevier Science, 1967 |g 50(2017), 16, Seite 942-946 |h Online-Ressource |w (DE-627)306354764 |w (DE-600)1496880-0 |w (DE-576)094107882 |x 1873-2933 |7 nnas |a Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year |
| 773 | 1 | 8 | |g volume:50 |g year:2017 |g number:16 |g pages:942-946 |g extent:5 |a Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.clinbiochem.2017.05.017 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0009912017302515 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180619 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1059123908 |a Kühn, Tilman |m 1059123908:Kühn, Tilman |d 50000 |e 50000PK1059123908 |k 0/50000/ |p 9 |y j | ||
| 998 | |g 172809223 |a Kaaks, Rudolf |m 172809223:Kaaks, Rudolf |d 50000 |e 50000PK172809223 |k 0/50000/ |p 8 | ||
| 998 | |g 134103726 |a Hoffmeister, Michael |m 134103726:Hoffmeister, Michael |d 50000 |e 50000PH134103726 |k 0/50000/ |p 7 | ||
| 998 | |g 1025332342 |a Bugert, Peter |m 1025332342:Bugert, Peter |d 60000 |d 63500 |e 60000PB1025332342 |e 63500PB1025332342 |k 0/60000/ |k 1/60000/63500/ |p 6 | ||
| 998 | |g 13177526X |a Johnson, Theron S. |m 13177526X:Johnson, Theron S. |d 50000 |e 50000PJ13177526X |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1576537668 |e 3013049839 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"5 S."}],"note":["Gesehen am 19.06.2018","Available online 29 May 2017"],"relHost":[{"title":[{"subtitle":"official journal of the Canadian Society of Clinical Chemists","title":"Clinical biochemistry","title_sort":"Clinical biochemistry"}],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"Canadian Society of Clinical Chemists"}],"part":{"volume":"50","pages":"942-946","extent":"5","year":"2017","issue":"16","text":"50(2017), 16, Seite 942-946"},"language":["eng"],"id":{"zdb":["1496880-0"],"issn":["1873-2933"],"eki":["306354764"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 04.02.20"],"recId":"306354764","disp":"Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one yearClinical biochemistry","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1967/68 -"],"origin":[{"publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1967","dateIssuedDisp":"1967-"}]}],"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"2017"}],"name":{"displayForm":["Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn"]},"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Graf, Mirja E.","family":"Graf","given":"Mirja E."},{"given":"Disorn","display":"Sookthai, Disorn","family":"Sookthai","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Theron S.","family":"Johnson","display":"Johnson, Theron S.","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Schübel","display":"Schübel, Ruth","given":"Ruth"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Katzke","display":"Katzke, Verena","given":"Verena"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Peter","display":"Bugert, Peter","family":"Bugert"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Michael","display":"Hoffmeister, Michael","family":"Hoffmeister"},{"display":"Kaaks, Rudolf","family":"Kaaks","given":"Rudolf","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Kühn, Tilman","family":"Kühn","given":"Tilman"}],"recId":"1576537668","id":{"doi":["10.1016/j.clinbiochem.2017.05.017"],"eki":["1576537668"]},"language":["eng"],"title":[{"title":"Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year","title_sort":"Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year"}]} | ||
| SRT | |a GRAFMIRJAEBIOLOGICAL2017 | ||