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Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year

Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be...

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Hauptverfasser: Graf, Mirja E. (VerfasserIn) , Sookthai, Disorn (VerfasserIn) , Johnson, Theron S. (VerfasserIn) , Schübel, Ruth (VerfasserIn) , Katzke, Verena (VerfasserIn) , Bugert, Peter (VerfasserIn) , Hoffmeister, Michael (VerfasserIn) , Kaaks, Rudolf (VerfasserIn) , Kühn, Tilman (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Clinical biochemistry
Year: 2017, Jahrgang: 50, Heft: 16, Pages: 942-946
ISSN:1873-2933
DOI:10.1016/j.clinbiochem.2017.05.017
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.clinbiochem.2017.05.017
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0009912017302515
Volltext
Verfasserangaben:Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn
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Zusammenfassung:Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be used as reliable biomarkers of platelet activation in epidemiological studies. Methods: We measured circulating P-Selectin, TM, TPO and GPIIb/IIIa by immunoassays in two blood samples of 78 participants of the EPIC Heidelberg study (47-80years, 50% female) that were collected one year apart. Biological reproducibility of biomarker levels over time and associations with routine biochemistry parameters were assessed by Spearman's correlation coefficients. Results: Statistical analyses revealed good reproducibility over one year for two of the analyzed markers, with Spearman coefficients of ρ=0.80 (P-Selectin) and ρ=0.73 (TPO) and reasonable reproducibility for TM (ρ=0.63) and GPIIb/IIIa (ρ=0.51). Levels of P-Selectin, TM, TPO and GPIIb/IIIa were not significantly associated with routine biochemistry parameters, such as glucose, HbA1c, LDL, HDL, Triglycerides and CRP. Conclusions: Our findings suggest that a single assessment of P-Selectin, TM, TPO and GPIIb/IIIa at baseline in prospective epidemiological studies is appropriate to investigate associations between platelet activation and risks of chronic diseases.
Beschreibung:Gesehen am 19.06.2018
Available online 29 May 2017
Beschreibung:Online Resource
ISSN:1873-2933
DOI:10.1016/j.clinbiochem.2017.05.017

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