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Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based...

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Bibliographic Details
Main Authors: Mattheisen, Manuel (Author) , Strohmaier, Jana (Author) , Treutlein, Jens (Author) , Meier, Sandra Melanie (Author) , Witt, Stephanie (Author) , Rietschel, Marcella (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Schizophrenia research
Year: 2012, Volume: 141, Issue: 2, Pages: 262-265
ISSN:1573-2509
DOI:10.1016/j.schres.2012.08.027
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.schres.2012.08.027
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0920996412005105
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Author Notes:Manuel Mattheisen, Thomas W. Mühleisen, Jana Strohmaier, Jens Treutlein, Igor Nenadic, Margrieta Alblas, Sandra Meier, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Stephanie H. Witt, Ina Giegling, Heinrich Sauer, Thomas G. Schulze, Dan Rujescu, Markus M. Nöthen, Marcella Rietschel, Sven Cichon
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Summary:Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value=0.0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.
Item Description:Available online 24 September 2012
Gesehen am 20.06.2018
Physical Description:Online Resource
ISSN:1573-2509
DOI:10.1016/j.schres.2012.08.027

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