A neurophysiological marker of impaired preparation in an 11-year follow-up study of attention-deficit/hyperactivity disorder (ADHD)
Background: This longitudinal electrophysiological study investigated the course of multiple impaired cognitive brain functions in attention-deficit/hyperactivity disorder (ADHD) from childhood to adulthood by comparing developmental trajectories of individuals with ADHD and typically developing con...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
The journal of child psychology and psychiatry
Year: 2012, Jahrgang: 54, Heft: 3, Pages: 260-270 |
| ISSN: | 1469-7610 |
| DOI: | 10.1111/j.1469-7610.2012.02572.x |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1111/j.1469-7610.2012.02572.x Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7610.2012.02572.x 
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| Verfasserangaben: | Mirko Doehnert, Daniel Brandeis, Gudrun Schneider, Renate Drechsler and Hans-Christoph Steinhausen |
| Zusammenfassung: | Background: This longitudinal electrophysiological study investigated the course of multiple impaired cognitive brain functions in attention-deficit/hyperactivity disorder (ADHD) from childhood to adulthood by comparing developmental trajectories of individuals with ADHD and typically developing controls. Methods: Subjects with ADHD (N = 11) and normal controls (N = 12) diagnosed in childhood [mean age ADHD/CTRL = 10.9 years [SD 1.72]/10.0 years (SD 1.03)] were followed up after 1.1 and 2.4 years, and as young adults [ADHD/CTRL: 21.9 years (SD 1.46)/21.1 years (SD 1.29)]. At all four times, event-related potential (ERP) maps were recorded during a cued continuous performance test (CPT). We focused on residual deficits as adults, and on developmental trajectories (time and time × group effects) for CPT performance and attentional (Cue P300), preparatory (CNV: contingent negative variation) and inhibitory (NoGo P300) ERP components. Results: All ERP components developed without significant time × group interactions. Only the CNV remained reduced in the ADHD group, although 8/11 individuals no longer met a full ADHD diagnosis as adults. Cue P300 and NoGo P300 group differences became nonsignificant in early adulthood. The CNV parameters correlated with reaction time (RT) and RT-SD. Perceptual sensitivity improved and the groups’ trajectories converged with development, while RT-SD continued to be elevated in adult ADHD subjects. Conclusions: Attentional and preparatory deficits in ADHD continue into adulthood, and the attenuated CNV appears to reflect a particularly stable ADHD marker. Although some deficit reductions may have gone undetected due to small sample size, the findings challenge those developmental lag models postulating that most ADHD-related deficits become negligible with brain maturation. |
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| Beschreibung: | First published: 13 July 2012 Gesehen am 20.06.2016 |
| Beschreibung: | Online Resource |
| ISSN: | 1469-7610 |
| DOI: | 10.1111/j.1469-7610.2012.02572.x |