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Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma

In multiple myeloma, focal lesions, as well as diffuse and variegated infiltration patterns, can be detected by magnetic resonance imaging. In the current study, we compared treatment response in 100 myeloma patients with changes in infiltration patterns in whole body magnetic resonance imaging befo...

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Main Authors: Hillengaß, Jens (Author) , Shah, Sofia (Author) , Kilk, Kerstin (Author) , Weber, Marc-André (Author) , Hielscher, Thomas (Author) , Hose, Dirk (Author) , Delorme, Stefan (Author) , Goldschmidt, Hartmut (Author) , Neben, Kai (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Haematologica, the hematology journal
Year: 2012, Volume: 97, Issue: 11, Pages: 1757-1760
ISSN:1592-8721
DOI:10.3324/haematol.2012.065359
Online Access:Verlag, Volltext: http://dx.doi.org/10.3324/haematol.2012.065359
Verlag, Volltext: http://www.haematologica.org/content/97/11/1757
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Author Notes:Jens Hillengass, Sofia Ayyaz, Kerstin Kilk, Marc-André Weber, Thomas Hielscher, Rajiv Shah, Dirk Hose, Stefan Delorme, Hartmut Goldschmidt, and Kai Neben
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Summary:In multiple myeloma, focal lesions, as well as diffuse and variegated infiltration patterns, can be detected by magnetic resonance imaging. In the current study, we compared treatment response in 100 myeloma patients with changes in infiltration patterns in whole body magnetic resonance imaging before and after autologous stem cell transplantation. We found an agreement between serological response and changes in imaging (P<0.001). In detail, a significant agreement of treatment response was observed for diffuse (P=0.004) as well as for focal (P=0.01) infiltration patterns. The number of focal lesions at second magnetic resonance imaging was of prognostic significance for overall survival (P=0.001). We conclude that treatment response in myeloma goes along with a decrease in imaging findings. We suggest that residual disease after high-dose chemotherapy detected by magnetic resonance imaging increases the risk of relapse. Therefore, myeloma patients with such findings after treatment might benefit from further cytoreduction.
Item Description:Gesehen am 21.06.2018
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2012.065359

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