Extracellular regulation of BMP signaling: welcome to the matrix
Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding a...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Biochemical Society transactions
Year: 2017, Volume: 45, Issue: 1, Pages: 173-181 |
| ISSN: | 1470-8752 |
| DOI: | 10.1042/BST20160263 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1042/BST20160263 Verlag, Volltext: http://www.biochemsoctrans.org/content/45/1/173 
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| Author Notes: | Georg Sedlmeier and Jonathan P. Sleeman |
| Summary: | Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling. |
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| Item Description: | Version of record published: 15 February 2017 Gesehen am 25.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1470-8752 |
| DOI: | 10.1042/BST20160263 |