Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA2LEN study
The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Clinical and translational allergy
Year: 2017, Jahrgang: 7 |
| ISSN: | 2045-7022 |
| DOI: | 10.1186/s13601-017-0169-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13601-017-0169-4 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13601-017-0169-4 
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| Verfasserangaben: | Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger and Torsten Zuberbier |
| Zusammenfassung: | The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. |
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| Beschreibung: | Published online: 17 September 2017 Gesehen am 25.06.2018 Im Titelzusatz ist die Zahl 2 hochgestellt |
| Beschreibung: | Online Resource |
| ISSN: | 2045-7022 |
| DOI: | 10.1186/s13601-017-0169-4 |