Novel options for the treatment of castration-resistant prostate cancer
Docetaxel had been the only treatment of castration-resistant prostate cancer (CRPC) that demonstrated a survival benefit for the patients. After its approval, no considerable progress has been made for several years until cabazitaxel and abiraterone acetate demonstrated a significant survival benef...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
|
| In: |
World journal of urology
Year: 2012, Volume: 30, Issue: 4, Pages: 495-503 |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-011-0796-7 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00345-011-0796-7 Verlag, Volltext: https://link.springer.com/article/10.1007/s00345-011-0796-7 
|
| Author Notes: | Carsten-H. Ohlmann, Axel S. Merseburger, Henrik Suttmann, David Schilling, Lutz Trojan, Carsten Kempkensteffen, Stefan Corvin, Michael J. Mathers, Patrick J. Bastian |
| Summary: | Docetaxel had been the only treatment of castration-resistant prostate cancer (CRPC) that demonstrated a survival benefit for the patients. After its approval, no considerable progress has been made for several years until cabazitaxel and abiraterone acetate demonstrated a significant survival benefit in phase III clinical trials. Apart from that several other new drugs appeared including inhibitors of the androgen receptor (MDV3100), endothelin receptor antagonists (atrasentan, zibotentan), bone-targeted drugs (denosumab, Alpharadin) and immunotherapies (sipuleucel-T) capable of improving the prognosis of patients with CRPC. Here, we review the most recent advances in the treatment of CRPC and highlight the most promising new agents currently being investigated in clinical trials. |
|---|---|
| Item Description: | Published online: 20 November 2011 Gesehen am 26.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-011-0796-7 |