Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity

Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain.

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Bibliographic Details
Main Authors:	Luo, Ceng (Author) , Gangadharan, Vijayan (Author) , Bali, Kiran Kumar (Author) , Agarwal, Nitin (Author) , Kurejova, Martina (Author) , Tappe-Theodor, Anke (Author) , Kuner, Thomas (Author) , Kuner, Rohini (Author)
Format:	Article (Journal)
Language:	English
Published:	2012
In:	PLoS biology Year: 2012, Volume: 10, Issue: 3
ISSN:	1545-7885
DOI:	10.1371/journal.pbio.1001283
Online Access:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pbio.1001283 Verlag, kostenfrei, Volltext: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001283
Author Notes:	Ceng Luo, Vijayan Gangadharan, Kiran Kumar Bali, Rou-Gang Xie, Nitin Agarwal, Martina Kurejova, Anke Tappe-Theodor, Irmgard Tegeder, Susanne Feil, Gary Lewin, Erika Polgar, Andrew J. Todd, Jens Schlossmann, Franz Hofmann, Da-Lu Liu, San-Jue Hu, Robert Feil, Thomas Kuner, Rohini Kuner

Description
Summary:	Electrophysiological and behavioral experiments in mice reveal that a cGMP-dependent kinase amplifies neurotransmitter release from peripheral pain sensors, potentiates spinal synapses, and leads to exaggerated pain.
Item Description:	Published March 13, 2012 Gesehen am 26.06.2018
Physical Description:	Online Resource
ISSN:	1545-7885
DOI:	10.1371/journal.pbio.1001283