Circadian variations in exsorptive transport: in situ intestinal perfusion data and in vivo relevance
The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein (P-gp) is a drug transporter that plays a pivotal role in drug absorption, distribution, and elimination, and temporal changes in its activit...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Chronobiology international
Year: 2012, Volume: 29, Issue: 4, Pages: 443-453 |
| ISSN: | 1525-6073 |
| DOI: | 10.3109/07420528.2012.668996 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3109/07420528.2012.668996
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| Author Notes: | Alper Okyar, Cornelia Dressler, Abeer Hanafy, Gül Baktir, Björn Lemmer, Hilde Spahn-Langguth |
| Summary: | The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein (P-gp) is a drug transporter that plays a pivotal role in drug absorption, distribution, and elimination, and temporal changes in its activity may affect input, output, activity, and toxicity profile of drugs. In the current study, the influence of different circadian stages on the overall intestinal permeability (Peff) of the P-gp substrates talinolol and losartan was evaluated in in situ intestinal perfusion studies in rats. |
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| Item Description: | Published online: 11 Apr 2012 Gesehen am 27.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1525-6073 |
| DOI: | 10.3109/07420528.2012.668996 |