Circadian variations in exsorptive transport: in situ intestinal perfusion data and in vivo relevance
The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein (P-gp) is a drug transporter that plays a pivotal role in drug absorption, distribution, and elimination, and temporal changes in its activit...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
|
| In: |
Chronobiology international
Year: 2012, Volume: 29, Issue: 4, Pages: 443-453 |
| ISSN: | 1525-6073 |
| DOI: | 10.3109/07420528.2012.668996 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3109/07420528.2012.668996
|
| Author Notes: | Alper Okyar, Cornelia Dressler, Abeer Hanafy, Gül Baktir, Björn Lemmer, Hilde Spahn-Langguth |