Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: results from a large, population-based cohort study with 14 years of follow-up
Background: Urinary 8‐isoprostane is an established biomarker for lipid peroxidation. However, the association between its pre-diagnostic levels and cancer incidence has rarely been evaluated. Methods: 8793 older adults from the German ESTHER cohort were followed up for cancer incidence by cancer re...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Free radical biology and medicine
Year: 2018, Volume: 123, Pages: 20-26 |
| ISSN: | 1873-4596 |
| DOI: | 10.1016/j.freeradbiomed.2018.05.065 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.065 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S089158491830889X 
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| Author Notes: | Xīn Gào, Hermann Brenner, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Ben Schöttker |
| Summary: | Background: Urinary 8‐isoprostane is an established biomarker for lipid peroxidation. However, the association between its pre-diagnostic levels and cancer incidence has rarely been evaluated. Methods: 8793 older adults from the German ESTHER cohort were followed up for cancer incidence by cancer registry data. A directed acyclic graph was utilized to identify potential confounders. Multivariate Cox regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). Results: During 14-year follow-up, 1540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were detected. 8-isoprostane concentrations were positively associated with lung cancer, but not with cancer at the other sites. The HR (95% CI) for the association with lung cancer was 1.61 (1.10, 2.34) for comparison of the top with bottom tertile in total population. The association of 8-isoprostane levels with lung cancer persisted after the adjustment for smoking and other potential confounders and was multiplicative to the effect of smoking. However, 8-isoprostane levels did not improve lung cancer prediction when added to a model containing age, sex and smoking. A protective association of increasing 8-isoprostane levels was observed for prostate cancer incidence but this association was only statistically significant among current smokers. Discussion: Our findings suggest that lipid peroxidation is involved in the development of lung cancer. However, high oxidative stress may be a protective factor for prostate cancer, especially among current smokers. |
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| Item Description: | Available online 17 May 2018 Gesehen am 27.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4596 |
| DOI: | 10.1016/j.freeradbiomed.2018.05.065 |