Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw: a randomized controlled feasibility study
Recent studies have indicated that bone shows auto-fluorescence under an appropriate fluorescence lamp. The aim of this preliminary study was to compare the success rates of the established tetracycline fluorescence-guided bone surgery with auto-fluorescence-guided bone surgery in the treatment of m...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
International journal of oral and maxillofacial surgery
Year: 2016, Volume: 46, Issue: 2, Pages: 157-166 |
| ISSN: | 1399-0020 |
| DOI: | 10.1016/j.ijom.2016.10.008 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijom.2016.10.008 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0901502716302818 
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| Author Notes: | O. Ristow, S. Otto, C. Geiß, V. Kehl, M. Berger, M. Troeltzsch, S. Koerdt, B. Hohlweg-Majert, C. Freudlsperger, C. Pautke |
| Summary: | Recent studies have indicated that bone shows auto-fluorescence under an appropriate fluorescence lamp. The aim of this preliminary study was to compare the success rates of the established tetracycline fluorescence-guided bone surgery with auto-fluorescence-guided bone surgery in the treatment of medication-related osteonecrosis of the jaw (MRONJ). Forty patients suffering from MRONJ were referred for surgical treatment and were divided randomly into two groups: auto-fluorescence (n=20) or tetracycline fluorescence (n=20) guided bone surgery. The primary endpoint was treatment success, defined as the absence of exposed bone at 8 weeks after surgery. Secondary outcomes assessed were mucosal integrity, signs of infection, pain, and loss of sensitivity; these were evaluated descriptively at 10 days, 8 weeks, 6 months, and 1 year after surgery. At 8 weeks postoperative, 18/20 patients (90%) in the auto-fluorescence group and 17/20 patients (85%) in the tetracycline fluorescence group showed mucosal integrity (P>0.05). At the last follow-up, 94% in the auto-fluorescence group and 89% in the tetracycline fluorescence group presented complete mucosal coverage with no exposed bone, infection, or pain (P>0.05). There was no significant difference between the two techniques for any of the secondary outcomes (P>0.05). The results of this preliminary study show that auto-fluorescence-guided bone surgery has comparable success rates to the established tetracycline fluorescence-guided bone surgery. |
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| Item Description: | Available online14 November 2016 Available online 14 November 2016 Gesehen am 28.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1399-0020 |
| DOI: | 10.1016/j.ijom.2016.10.008 |