Cover Image

Effects of a preconditioning oral nutritional supplement on pig livers after warm ischemia

Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI). This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pi...

Full description

Saved in:
Bibliographic Details
Main Authors: Nickkholgh, Arash (Author) , Li, Zhanqing (Author) , Liang, Rui (Author) , Mikalauskas, Saulius (Author) , Groß-Weissmann, Marie-Luise (Author) , Zorn, Markus (Author) , Büchler, Markus W. (Author) , Schemmer, Peter (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: HPB surgery

ISSN:1607-8462
DOI:10.1155/2012/783479
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2012/783479
Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/hpb/2012/783479/
Get full text
Author Notes:Arash Nickkholgh, Zhanqing Li, Xue Yi, Elvira Mohr, Rui Liang, Saulius Mikalauskas, Marie-Luise Gross, Markus Zorn, Steffen Benzing, Heinz Schneider, Markus W. Büchler, and Peter Schemmer
Description
Summary:Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI). This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pigs. Methods. pONS (70 g per serving, Fresenius Kabi, Germany) was dissolved in 250 mL tap water and given to pigs 24, 12, and 2 hrs before warm ischemia of the liver. A fourth dose was given 3 hrs after reperfusion. Controls were given the same amount of cellulose with the same volume of water. Two hours after the third dose of pONS, both the portal vein and the hepatic artery were clamped for 40 min. 0.5, 3, 6, and 8 hrs after reperfusion, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), portal venous flow (PVF), hepatic arterial flow (HAF), bile flow, and transaminases were measured. Liver tissue was taken 8 hrs after reperfusion for histology and immunohistochemistry.
Item Description:Gesehen am 28.06.2018
Physical Description:Online Resource
ISSN:1607-8462
DOI:10.1155/2012/783479

Similar Items