Prediction of adverse clinical outcome in patients with acute pulmonary embolism: evaluation of high-sensitivity troponin I and quantitative CT parameters
PURPOSE: To evaluate the accuracy of high-sensitivity-cardiac-troponin-I (hs-cTnI) and quantitative CT-parameters, alone and in combination, for predicting right-ventricular-dysfunction (RVD) and adverse clinical outcome in patients with acute pulmonary embolism (PE). MATERIALS AND METHODS: 65 patie...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
European journal of radiology
Year: 2012, Volume: 82, Issue: 3, Pages: 563-567 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2012.11.009 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejrad.2012.11.009 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X12005529 
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| Author Notes: | Paul Apfaltrer, Thomas Walter, Joachim Gruettner, Frank Weilbacher, Mathias Meyer, Thomas Henzler, Michael Neumaier, Stefan O. Schoenberg, Christian Fink |
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| 245 | 1 | 0 | |a Prediction of adverse clinical outcome in patients with acute pulmonary embolism |b evaluation of high-sensitivity troponin I and quantitative CT parameters |c Paul Apfaltrer, Thomas Walter, Joachim Gruettner, Frank Weilbacher, Mathias Meyer, Thomas Henzler, Michael Neumaier, Stefan O. Schoenberg, Christian Fink |
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| 520 | |a PURPOSE: To evaluate the accuracy of high-sensitivity-cardiac-troponin-I (hs-cTnI) and quantitative CT-parameters, alone and in combination, for predicting right-ventricular-dysfunction (RVD) and adverse clinical outcome in patients with acute pulmonary embolism (PE). MATERIALS AND METHODS: 65 patients with PE and hs-cTnI measurements within 24 h of CT were retrospectively included. RVD was assessed on CT by calculating right ventricular/left ventricular (RV/LV) diameter ratios on transverse sections (RV/LVtrans), four-chamber-views (RV/LV4ch), and RV/LV volume ratio (RV/LVvol). Pulmonary CTA-obstruction-scores (OS) (Qanadli, Mastora) were calculated. Receiver operator characteristic (ROC) analysis was performed to compare Hs-cTnI, RV/LV ratios, and OS for predicting adverse clinical outcome (i.e. intensive care treatment, death). RESULTS: 12 patients with PE had adverse clinical outcome and showed significantly higher RV/LV ratios and OS compared to those without. ROC analysis revealed a cutoff value of 0.042 ng/mL for hs-cTnI resulting in a sensitivity and specificity of 84% and 92% for predicting adverse clinical outcome, respectively. Elevated hs-cTnI was significantly associated with adverse clinical outcome. In a ROC analysis the AUC for the prediction of adverse clinical outcome of RV/LV4Ch, RV/LVvol, and hs-cTnI were 0.77, 0.76, and 0.71. The combination of hs-cTnI and RV/LV ratios increased the AUC for the prediction of adverse clinical outcome. CONCLUSIONS: Hs-cTnI is associated with adverse clinical outcome in patients with acute PE. A combination of hs-cTnI with quantitative CT-parameters improves the prediction of adverse clinical outcome. | ||
| 534 | |c 2012 | ||
| 650 | 4 | |a Acute Disease | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Pulmonary Embolism | |
| 650 | 4 | |a Reproducibility of Results | |
| 650 | 4 | |a Retrospective Studies | |
| 650 | 4 | |a Risk Assessment | |
| 650 | 4 | |a Sensitivity and Specificity | |
| 650 | 4 | |a Tomography, X-Ray Computed | |
| 650 | 4 | |a Troponin I | |
| 650 | 4 | |a Ventricular Dysfunction, Right | |
| 650 | 4 | |a Young Adult | |
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