Potential relevance of shear stress for slit diaphragm and podocyte function
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot process...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Kidney international
Year: 2017, Volume: 91, Issue: 6, Pages: 1283-1286 |
| ISSN: | 1523-1755 |
| DOI: | 10.1016/j.kint.2017.02.032 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.kint.2017.02.032 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0085253817301746 
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| Author Notes: | Wilhelm Kriz, Kevin V. Lemley |
| Summary: | Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit. |
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| Item Description: | Available online 11 May 2017 Gesehen am 28.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1523-1755 |
| DOI: | 10.1016/j.kint.2017.02.032 |