Retinopathy in an obesity WHO III cohort: prevalence and risk factors
Objective: To assess retinopathy and its risk factors in an obesity WHO III cohort. Methods: In the Mannheim Obesity Study, 277 subjects with obesity WHO III aged 18-64 years were examined in a cross-sectional approach. Screening for retinopathy was performed using 3-field retinal photography. Endot...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 March 2017
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| In: |
British journal of ophthalmology
Year: 2017, Volume: 101, Issue: 11, Pages: 1550-1554 |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjophthalmol-2016-309566 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1136/bjophthalmol-2016-309566 Verlag, kostenfrei, Volltext: https://bjo-bmj-com.ezproxy.medma.uni-heidelberg.de/content/101/11/1550 
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| Author Notes: | Juri Mattern, Alexander Lammert, Mirko Otto, Hans-Peter Hammes |
| Summary: | Objective: To assess retinopathy and its risk factors in an obesity WHO III cohort. Methods: In the Mannheim Obesity Study, 277 subjects with obesity WHO III aged 18-64 years were examined in a cross-sectional approach. Screening for retinopathy was performed using 3-field retinal photography. Endothelial function was assessed using arteriole-to-venule ratio and flicker light analysis. Subjects with and without retinopathy were analysed for anthropometry, metabolic, vascular and renal parameters. Results: Retinopathy was found in 18 of the 277 subjects (6.5%). Prevalence of retinopathy was 16.7% in subjects with and 3.4% in subjects without diabetes mellitus. Between subjects with and without retinopathy there were significant differences in diabetes prevalence (61.1% vs 21.7%, p<0.001), systolic blood pressure (145.56 vs 131.73 mm Hg, p=0.005), intima-media thickness (0.7 vs 0.59 mm, p=0.034), dilatation of retinal veins in response to flicker light (2.24% vs 4.28%, p=0.004) and creatinine (0.92 vs 0.83 mg/dL, p=0.011). Stepwise logistic regression analysis revealed that the presence of diabetes mellitus led to an 8.3-fold increased risk for retinopathy (OR 8.3, p=0.049, 95% CI 1.01 to 67.49), whereas risk for retinopathy decreased by nearly 50% (OR 0.54, p=0.032, 95% CI 0.30 to 0.95) with each percentage increase in venous dilatation in response to flicker light. Conclusions: Retinopathy prevalence in our obesity WHO III cohort is low. Presence of diabetes mellitus is the most important risk factor for retinopathy. Preserved venular function indicates protection from retinopathy. |
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| Item Description: | Published online first 17 March 2017 Gesehen am 04.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjophthalmol-2016-309566 |