Methodological aspects of clinical trials in tinnitus: a proposal for an international standard
Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heter...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 June 2012
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| In: |
Journal of psychosomatic research
Year: 2012, Volume: 73, Issue: 2, Pages: 112-121 |
| ISSN: | 1879-1360 |
| DOI: | 10.1016/j.jpsychores.2012.05.002 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jpsychores.2012.05.002 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022399912001249 
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| Author Notes: | Michael Landgrebe, Andréia Azevedo, David Baguley, Carol Bauer, Anthony Cacace, Claudia Coelho, John Dornhoffer, Ricardo Figueiredo, Herta Flor, Goeran Hajak, Paul van de Heyning, Wolfgang Hiller, Eman Khedr, Tobias Kleinjung, Michael Koller, Jose Miguel Lainez, Alain Londero, William H. Martin, Mark Mennemeier, Jay Piccirillo, Dirk De Ridder, Rainer Rupprecht, Grant Searchfield, Sven Vanneste, Florian Zeman, Berthold Langguth |
| Summary: | Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison between studies. Here, we discuss our view of the most important aspects of trial design in clinical studies in tinnitus and make suggestions for an international methodological standard in tinnitus trials. We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus. |
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| Item Description: | Gesehen am 09.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1360 |
| DOI: | 10.1016/j.jpsychores.2012.05.002 |