Calcium signaling and transcriptional regulation in cardiomyocytes
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes, Ca2+ is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Di...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 29, 2017
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| In: |
Circulation research
Year: 2017, Jahrgang: 121, Heft: 8, Pages: 1000-1020 |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.117.310355 |
| Online-Zugang: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.1161/CIRCRESAHA.117.310355 Verlag, teilw. kostenfrei, Volltext: http://circres.ahajournals.org.ezproxy.medma.uni-heidelberg.de/content/121/8/1000 
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| Verfasserangaben: | Matthias Dewenter, Albert von der Lieth, Hugo A. Katus, Johannes Backs |
| Zusammenfassung: | Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes, Ca2+ is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Disturbances in cellular Ca2+-handling and alterations in Ca2+-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcription coupling pathways shown to be critically involved in structural and functional remodeling processes. Thus, targeting Ca2+-dependent transcriptional pathways might offer broad therapeutic potential. In this article, we (1) review cytosolic and nuclear Ca2+ dynamics in cardiomyocytes with respect to their impact on Ca2+-dependent signaling, (2) give an overview on Ca2+-dependent transcriptional pathways in cardiomyocytes, and (3) discuss implications of excitation-transcription coupling in the diseased heart. |
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| Beschreibung: | Originally published: September 28, 2017 Gesehen am 09.07.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.117.310355 |