Histogram based analysis of lung perfusion of children after congenital diaphragmatic hernia repair
Objectives To investigate a histogram based approach to characterize the distribution of perfusion in the whole left and right lung by descriptive statistics and to show how histograms could be used to visually explore perfusion defects in two year old children after Congenital Diaphragmatic Hernia...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Magnetic resonance imaging
Year: 2017, Volume: 48, Pages: 42-49 |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/j.mri.2017.11.013 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.mri.2017.11.013 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0730725X17302643 
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| Author Notes: | Nora Kassner, Meike Weis, Katrin Zahn, Thomas Schaible, Stefan O. Schoenberg, Lothar R. Schad, Frank G. Zöllner |
| Summary: | Objectives To investigate a histogram based approach to characterize the distribution of perfusion in the whole left and right lung by descriptive statistics and to show how histograms could be used to visually explore perfusion defects in two year old children after Congenital Diaphragmatic Hernia (CDH) repair. Methods 28 children (age of 24.2±1.7months; all left sided hernia; 9 after extracorporeal membrane oxygenation therapy) underwent quantitative DCE-MRI of the lung. Segmentations of left and right lung were manually drawn to mask the calculated pulmonary blood flow maps and then to derive histograms for each lung side. Individual and group wise analysis of histograms of left and right lung was performed. Results Ipsilateral and contralateral lung show significant difference in shape and descriptive statistics derived from the histogram (Wilcoxon signed-rank test, p<0.05) on group wise and individual level. Subgroup analysis (patients with vs without ECMO therapy) showed no significant differences using histogram derived parameters. Conclusions Histogram analysis can be a valuable tool to characterize and visualize whole lung perfusion of children after CDH repair. It allows for several possibilities to analyze the data, either describing the perfusion differences between the right and left lung but also to explore and visualize localized perfusion patterns in the 3D lung volume. Subgroup analysis will be possible given sufficient sample sizes. |
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| Item Description: | Available online 23 November 2017 Available online: 23 November 2017 Gesehen am 10.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/j.mri.2017.11.013 |