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Circulating dopamine and c-peptide levels in fasting nondiabetic hypertensive patients: the Graz endocrine causes of hypertension study

OBJECTIVE: Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. RESEARCH DESIGN AND METHODS:...

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Bibliographic Details
Main Authors: Tomaschitz, Andreas (Author) , Ritz, Eberhard (Author) , März, Winfried (Author) , Pilz, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Diabetes care
Year: 2012, Volume: 35, Issue: 8, Pages: 1771-1773
ISSN:1935-5548
DOI:10.2337/dc11-2384
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.2337/dc11-2384
Verlag, kostenfrei, Volltext: http://care.diabetesjournals.org/content/35/8/1771
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Author Notes:Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
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Summary:OBJECTIVE: Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. RESEARCH DESIGN AND METHODS: After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 ± 16.0 years; 61.7% women). RESULTS: Mean dopamine and C-peptide concentration were 33.4 ± 38.6 pg/mL and 3.1 ± 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = −0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% CI 2.9-4.1]) to tertile 3 (1.6 ng/mL [1.5-2.7], P < 0.001) after multivariate adjustment. CONCLUSIONS: The inverse association between dopamine and C-peptide highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function.
Item Description:Gesehen am 11.07.2018
Physical Description:Online Resource
ISSN:1935-5548
DOI:10.2337/dc11-2384

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