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Progressive dispersion of azole resistance in Aspergillus fumigatus: fatal invasive Aspergillosis in a patient with acute myeloid leukemia infected with an A. fumigatus strain with a cyp51A TR46 Y121F M172I T289A allele

Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaco...

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Bibliographic Details
Main Authors: Rößler, Susann (Author) , Spiess, Birgit (Author) , Buchheidt, Dieter (Author)
Format: Article (Journal)
Language:English
Published: July 25, 2017
In: Antimicrobial agents and chemotherapy
Year: 2017, Volume: 61, Issue: 8
ISSN:1098-6596
DOI:10.1128/AAC.00270-17
Online Access:Verlag, Volltext: http://dx.doi.org/10.1128/AAC.00270-17
Verlag, Volltext: http://aac.asm.org/content/61/8/e00270-17
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Author Notes:Susann Rößler, Oliver Bader, Friedrich Stölzel, Ulrich Sommer, Birgit Spiess, Stephan Geibel, Dieter Buchheidt, Uwe Groß, Gustavo Baretton, Enno Jacobs ; Luis Ostrosky-Zeichner (commentator)
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Summary:Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaconazole prophylaxis. The agent was determined to be an azole-resistant Aspergillus fumigatus strain bearing the cyp51A mutation combination TR46 Y121F M172I T289A. At increasing frequency, the azole resistance of A. fumigatus is being reported globally, limiting treatment options and complicating regimens.
Item Description:Gesehen am 12.07.2018
Im Titel ist "46" tiefgestellt
Physical Description:Online Resource
ISSN:1098-6596
DOI:10.1128/AAC.00270-17

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