Duration of type 2 diabetes strongly predicts all-cause and cardiovascular mortality in people referred for coronary angiography
Objective - Type 2 diabetes represents a major cardiovascular risk factor. However, few studies have addressed the impact of the disease duration on mortality. Thus, we aimed to investigate the predictive value of diabetes duration for all-cause and cardiovascular mortality in subjects undergoing co...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2012
|
| In: |
Atherosclerosis
Year: 2012, Jahrgang: 221, Heft: 2, Pages: 551-557 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2012.01.011 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.atherosclerosis.2012.01.011 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915012000445 
|
| Verfasserangaben: | Guenther Silbernagel, Silke Rosinger, Tanja B. Grammer, Marcus E. Kleber, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März |
| Zusammenfassung: | Objective - Type 2 diabetes represents a major cardiovascular risk factor. However, few studies have addressed the impact of the disease duration on mortality. Thus, we aimed to investigate the predictive value of diabetes duration for all-cause and cardiovascular mortality in subjects undergoing coronary angiography. - Methods - We studied 2455 participants of the LUdwigshafen RIsk and Cardiovascular health study (1768 males/687 females). They had a mean±standard deviation (SD) age of 63.1±9.0 years (range: 40.0-79.9) and a mean±SD body mass index of 27.7±4.0kg/m2. 704 subjects were newly diagnosed with type 2 diabetes according to the 2010 criteria of the American Diabetes Association and 446 subjects had a known history of type 2 diabetes. The mean±SD duration of the follow-up for all-cause and cardiovascular mortality was 7.4±2.3 years. - Results - A total of 543 deaths occurred during the follow-up. Among these, 343 were accounted for by cardiovascular diseases. The duration of type 2 diabetes was strongly and positively correlated with all-cause and cardiovascular mortality (both P<0.001). The multivariate adjusted hazard ratios (95% confidence intervals) for cardiovascular mortality compared to subjects without diabetes were 1.76 (1.34-2.32), 2.86 (2.00-4.08), 2.96 (1.85-4.74), and 4.55 (3.24-6.39) for subjects with new onset type 2 diabetes and subjects with known type 2 diabetes (duration ≤5, >5 and ≤10, >10 years), respectively. - Conclusions - The data emphasise the need to consider the diabetes duration for the prediction of mortality in subjects at intermediate to high cardiovascular risk. |
|---|---|
| Beschreibung: | Available online 11 January 2012 |
| Beschreibung: | Online Resource |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2012.01.011 |