Short-course radiation plus temozolomide in elderly patients with glioblastoma
Glioblastoma is a fatal illness that is associated with a median survival of less than 2 years. Population studies of glioblastoma have shown that survival declines with increasing age,1,2 and the incidence of glioblastoma is increasing, especially among the elderly.3 Older patients have been underr...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 16, 2017
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| In: |
The New England journal of medicine
Year: 2017, Volume: 376, Issue: 11, Pages: 1027-1037 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa1611977 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1056/NEJMoa1611977 Verlag, Volltext: https://doi.org/10.1056/NEJMoa1611977 
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| Author Notes: | James R. Perry, Normand Laperriere, Christopher J. O’Callaghan, Alba A. Brandes, Johan Menten, Claire Phillips, Michael Fay, Ryo Nishikawa, J. Gregory Cairncross, Wilson Roa, David Osoba, John P. Rossiter, Arjun Sahgal, Hal Hirte, Florence Laigle-Donadey, Enrico Franceschi, Olivier Chinot, Vassilis Golfinopoulos, Laura Fariselli, Antje Wick, Loic Feuvret, Michael Back, Michael Tills, Chad Winch, Brigitta G. Baumert, Wolfgang Wick, Keyue Ding, and Warren P. Mason |
| Summary: | Glioblastoma is a fatal illness that is associated with a median survival of less than 2 years. Population studies of glioblastoma have shown that survival declines with increasing age,1,2 and the incidence of glioblastoma is increasing, especially among the elderly.3 Older patients have been underrepresented in most randomized trials, in which the average age of participants is approximately 55 years, as compared with the population-based median for patients with glioblastoma of 65 years of age.2 In 2005, a phase 3 trial of radiotherapy alone (60 Gy over a period of 6 weeks) versus radiotherapy plus temozolomide showed longer survival . . . |
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| Item Description: | Gesehen am 19.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa1611977 |