Buchumschlag

Peripheral nerve diffusion tensor imaging (DTI): normal values and demographic determinants in a cohort of 60 healthy individuals

Objective: To identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). Methods: Sixty subjects were examined at 3 Tesla by single-sho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kronlage, Moritz (VerfasserIn) , Münch, Véronique (VerfasserIn) , Schwarz, Daniel (VerfasserIn) , Godel, Tim (VerfasserIn) , Uhlmann, Lorenz (VerfasserIn) , Heiland, Sabine (VerfasserIn) , Bendszus, Martin (VerfasserIn) , Bäumer, Philipp (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: European radiology
Year: 2018, Jahrgang: 28, Heft: 5, Pages: 1801-1808
ISSN:1432-1084
DOI:10.1007/s00330-017-5134-z
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1007/s00330-017-5134-z
Verlag, Volltext: https://link.springer.com/article/10.1007/s00330-017-5134-z
Volltext
Verfasserangaben:Moritz Kronlage, Véronique Schwehr, Daniel Schwarz, Tim Godel, Lorenz Uhlmann, Sabine Heiland, Martin Bendszus, Philipp Bäumer
Beschreibung
Zusammenfassung:Objective: To identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). Methods: Sixty subjects were examined at 3 Tesla by single-shot DTI. FA, AD, RD, and MD were collected for the sciatic, tibial, median, ulnar, and radial nerve and were correlated with demographic variables. Results: Mean FA of all nerves declined with increasing age (r = −0.77), which could be explained by RD increasing (r = 0.56) and AD declining (r = −0.40) with age. Moreover, FA was inversely associated with height (r = −0.28), weight (r = −0.38) and BMI (r = −0.35). Although FA tended to be lower in men than women (p = 0.052), this difference became completely negligible after adjustment to body weight. A multiple linear regression model for FA was calculated with age and weight as predictors (defined by backward variable selection), yielding an R 2 = 0.71 and providing a correction formula to adjust FA for age and weight. Conclusion: Peripheral nerve DTI parameters depend on demographic variables. The most important determinants age and weight should be considered in all studies employing peripheral nerve DTI. Key points • Peripheral nerve diffusion tensor imaging (DTI) parameters depend on demographic variables. • Fractional anisotropy (FA) declines with increasing age and weight. • Gender does not systematically affect peripheral nerve DTI. • The formula presented here allows adjustment of FA for demographic variables.
Beschreibung:First online: 11 December 2017
Gesehen am 19.07.2018
Beschreibung:Online Resource
ISSN:1432-1084
DOI:10.1007/s00330-017-5134-z

Ähnliche Einträge