A scavenger peptide prevents methylglyoxal induced pain in mice
The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteo...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Biochimica et biophysica acta. Molecular basis of disease
Year: 2017, Volume: 1863, Issue: 3, Pages: 654-662 |
| ISSN: | 1879-260X |
| DOI: | 10.1016/j.bbadis.2016.12.001 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.bbadis.2016.12.001 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0925443916303295 
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| Author Notes: | Sebastian Brings, Thomas Fleming, Svenja De Buhr, Barbro Beijer, Thomas Lindner, Artjom Wischnjow, Zoltan Kender, Verena Peters, Stefan Kopf, Uwe Haberkorn, Walter Mier, Peter P. Nawroth |
| Summary: | The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG. It was shown to reduce the formation of albumin-MG adducts in vitro and prevented MG-induced pain by reducing plasma MG levels through the formation of peptide-MG adducts in vivo. CycK(Myr)R4E therefore presents a promising option for the treatment of pain and other diabetic complications associated with high MG levels. |
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| Item Description: | Available online: 6 December 2016 Gesehen am 19.07.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1879-260X |
| DOI: | 10.1016/j.bbadis.2016.12.001 |