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Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses: an animal study

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Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition have been well described to reprogram the germline and subsequently offspring attributes,...

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Bibliographic Details
Main Authors: Glosse, Katharina (Author) , Schenz, Judith (Author) , Uhle, Sandra (Author) , Schaack, Dominik (Author) , Weigand, Markus A. (Author) , Uhle, Florian (Author)
Format: Article (Journal)
Language:English
Published: 28 June 2018
In: Clinical epigenetics
Year: 2018, Volume: 10
ISSN:1868-7083
DOI:10.1186/s13148-018-0522-z
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13148-018-0522-z
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-018-0522-z
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Author Notes:Katharina Bomans, Judith Schenz, Sandra Tamulyte, Dominik Schaack, Markus Alexander Weigand and Florian Uhle
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Summary:Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition have been well described to reprogram the germline and subsequently offspring attributes, the intergenerational impact of sepsis as a tremendous immunological stressor has not been examined yet.
Item Description:Gesehen am 20.07.2018
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-018-0522-z

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