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Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses: an animal study

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Sepsis represents the utmost severe consequence of infection, involving a dysregulated and self-damaging immune response of the host. While different environmental exposures like chronic stress or malnutrition have been well described to reprogram the germline and subsequently offspring attributes,...

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Main Authors: Glosse, Katharina (Author) , Schenz, Judith (Author) , Uhle, Sandra (Author) , Schaack, Dominik (Author) , Weigand, Markus A. (Author) , Uhle, Florian (Author)
Format: Article (Journal)
Language:English
Published: 28 June 2018
In: Clinical epigenetics
Year: 2018, Volume: 10
ISSN:1868-7083
DOI:10.1186/s13148-018-0522-z
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13148-018-0522-z
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-018-0522-z
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Author Notes:Katharina Bomans, Judith Schenz, Sandra Tamulyte, Dominik Schaack, Markus Alexander Weigand and Florian Uhle
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Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses: an animal study by Glosse, Katharina (Author) , Schenz, Judith (Author) , Uhle, Sandra (Author) , Schaack, Dominik (Author) , Weigand, Markus A. (Author) , Uhle, Florian (Author) ,

BioMed Central ; Springer 02 Jul. 2018 Universitätsbibliothek Heidelberg 02 Jul. 2018

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