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Expression and functional characterization of the BNIP3 Protein in renal cell carcinomas

BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patie...

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Main Authors: Macher-Göppinger, Stephan (Author) , Keith, Martina (Author) , Hatiboglu, Gencay (Author) , Hohenfellner, Markus (Author) , Schirmacher, Peter (Author) , Roth, Wilfried (Author) , Tagscherer, Katrin (Author)
Format: Article (Journal)
Language:English
Published: 15 September 2017
In: Translational oncology
Year: 2017, Volume: 10, Issue: 6, Pages: 869-875
ISSN:1936-5233
DOI:10.1016/j.tranon.2017.08.008
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.tranon.2017.08.008
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1936523317302917
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Author Notes:Stephan Macher-Goeppinger, Martina Keith, Gencay Hatiboglu, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth and Katrin E. Tagscherer
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Summary:BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell carcinomas (RCCs) and examined the functional relevance of BNIP3 in the regulation of cell survival and apoptosis of renal carcinoma cells. BNIP3 expression was determined by immunohistochemistry in RCC tumor tissue samples of 569 patients using a tissue microarray. Functional characterization of BNIP3 in renal carcinoma cells indicates prosurvival effects. In human RCC tumor samples, high cytoplasmic BNIP3 expression was associated with high-grade RCCs and regional lymph node metastasis. BNIP3 expression correlated negatively with disease-specific survival. Multivariate Cox regression analysis retained BNIP3 expression as an independent prognostic factor in patients without distant metastasis. Together, our studies imply that BNIP3 regulates cell survival in RCCs and its expression is an independent prognostic marker in patients with localized RCCs.
Item Description:Gesehen am 23.07.2018
Physical Description:Online Resource
ISSN:1936-5233
DOI:10.1016/j.tranon.2017.08.008

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