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Transient P2X7 receptor activation triggers macrophage death independent of toll-like receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins

Background: P2X7 receptors are thought to be primarily involved in inflammatory signaling. Results: Transient (1- 4 min) high ATP induced delayed (hours) cell death in macrophages from WT and TLR2/4, Casp1, or Panx1 knock-out mice. Conclusion: Transient P2X7 receptor activation triggers macrophage-s...

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Bibliographic Details
Main Authors: Hanley, Peter J. (Author) , Filippov, Mikhail A. (Author)
Format: Article (Journal)
Language:English
Published: January 10, 2012
In: The journal of biological chemistry
Year: 2012, Volume: 287, Issue: 13, Pages: 10650-10663
ISSN:1083-351X
DOI:10.1074/jbc.M111.332676
Online Access:Verlag, Volltext: http://dx.doi.org/10.1074/jbc.M111.332676
Verlag, Volltext: http://www.jbc.org/lookup/doi/10.1074/jbc.M111.332676
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Author Notes:Peter J. Hanley, Moritz Kronlage, Carsten Kirschning, Adriana del Rey, Francesco Di Virgilio, Jens Leipziger, Iain P. Chessell, Sarah Sargin, Mikhail A. Filippov, Otto Lindemann, Simon Mohr, Volker Königs, Hermann Schillers, Martin Bähler, and Albrecht Schwab
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Summary:Background: P2X7 receptors are thought to be primarily involved in inflammatory signaling. Results: Transient (1- 4 min) high ATP induced delayed (hours) cell death in macrophages from WT and TLR2/4, Casp1, or Panx1 knock-out mice. Conclusion: Transient P2X7 receptor activation triggers macrophage-selective apoptotic cell death independent of TLR signaling, Casp1, and Panx1. Significance: P2X7 receptors function foremost as death triggers in macrophages.
Item Description:Im Titel ist "7" tiefgestellt. - Gesehen am 24.07.2018
Physical Description:Online Resource
ISSN:1083-351X
DOI:10.1074/jbc.M111.332676

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