Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal t...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 Oct 2012
|
| In: |
OncoImmunology
Year: 2012, Jahrgang: 1, Heft: 6, Pages: 943-945 |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19789 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.4161/onci.19789 Verlag, kostenfrei, Volltext: https://doi.org/10.4161/onci.19789 
|
| Verfasserangaben: | Mengxian Zhang, Michael Lahn & Peter E. Huber |
| Zusammenfassung: | To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1 |
|---|---|
| Beschreibung: | Published online: 17 Oct 2012 Gesehen am 30.07.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19789 |