Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma

To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal t...

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Bibliographic Details
Main Authors: Zhang, Mengxian (Author) , Lahn, Michael (Author) , Huber, Peter E. (Author)
Format: Article (Journal)
Language:English
Published: 17 Oct 2012
In: OncoImmunology
Year: 2012, Volume: 1, Issue: 6, Pages: 943-945
ISSN:2162-402X
DOI:10.4161/onci.19789
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.4161/onci.19789
Verlag, kostenfrei, Volltext: https://doi.org/10.4161/onci.19789
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Author Notes:Mengxian Zhang, Michael Lahn & Peter E. Huber
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Summary:To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1
Item Description:Published online: 17 Oct 2012
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Physical Description:Online Resource
ISSN:2162-402X
DOI:10.4161/onci.19789