CD4+CD25+Foxp3+IFNγ+ Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC
IFNγ-producing CD3+CD4+CD25+Foxp3+ induced Treg are more frequently detectable in patients with good than in patients with impaired long-term kidney graft function. We investigated the in-vitro function of separated CD3+CD4+CD25+Foxp3+IFNγ+ PBL that were induced by phorbol-12-myristate-13-acetate(PM...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 August 2012
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| In: |
Transplant immunology
Year: 2012, Volume: 27, Issue: 2-3, Pages: 114-121 |
| ISSN: | 1878-5492 |
| DOI: | 10.1016/j.trim.2012.08.003 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.trim.2012.08.003 Verlag, Volltext: http://linkinghub.elsevier.com/retrieve/pii/S0966327412000883 
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| Author Notes: | Volker Daniel, Mahmoud Sadeghi, Haihao Wang, Gerhard Opelz |
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| 520 | |a IFNγ-producing CD3+CD4+CD25+Foxp3+ induced Treg are more frequently detectable in patients with good than in patients with impaired long-term kidney graft function. We investigated the in-vitro function of separated CD3+CD4+CD25+Foxp3+IFNγ+ PBL that were induced by phorbol-12-myristate-13-acetate(PMA)/Ionomycin or alloantigenic stimulation. Additionally, we studied iTreg induction and cell proliferation in MLC with pretransplant obtained PBL. | ||
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