Therapeutic monoclonal antibodies in combination with pomalidomide can overcome refractoriness to both agents in multiple myeloma: a case-based approach
In multiple myeloma (MM), the synergy between immunomodulatory drugs (IMiDs) and monoclonal antibodies (MABs) has been demonstrated in several pivotal trials. However, disease refractory to either class of compounds remains a major therapeutic challenge. We here report on 3 heavily pretreated MM pat...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Hematological oncology
Year: 2018, Volume: 36, Issue: 1, Pages: 258-261 |
| ISSN: | 1099-1069 |
| DOI: | 10.1002/hon.2473 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1002/hon.2473 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hon.2473 
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| Author Notes: | Marc-Andrea Baertsch, Michael Hundemer, Jens Hillengass, Hartmut Goldschmidt, Marc S. Raab |
| Summary: | In multiple myeloma (MM), the synergy between immunomodulatory drugs (IMiDs) and monoclonal antibodies (MABs) has been demonstrated in several pivotal trials. However, disease refractory to either class of compounds remains a major therapeutic challenge. We here report on 3 heavily pretreated MM patients who were refractory to pomalidomide as well as to MABs against CD38 (daratumumab) or CD20 (rituximab), respectively, but who responded to retreatment with the same agents in combination. Responses were durable with PFS of 7, 10 (ongoing), and 30 months from initiation of combination treatment. The combination of IMiDs with MABs directed against MM cell surface antigens can overcome refractoriness to both agents. |
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| Item Description: | Received: 4 March 2017 Revised: 17 July 2017 Accepted: 10 August 2017 Gesehen am 02.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1099-1069 |
| DOI: | 10.1002/hon.2473 |