Whole-body MRI in patients with non-bacterial osteitis: radiological findings and correlation with clinical data

OBJECTIVES: To correlate clinical findings of Non-bacterial Osteitis (NBO) with whole-body MRI (WB-MRI) findings and determine a radiologic index for NBO (RINBO) which allows standardized reporting of WB-MRI. METHODS AND MATERIALS: In a prospective study, 40 patients with diagnosis of NBO underwent...

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Main Authors: Arnoldi, Andreas Paul (Author) , Schlett, Christopher L. (Author) , Weckbach, Sabine (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: European radiology
Year: 2016, Volume: 27, Issue: 6, Pages: 2391-2399
ISSN:1432-1084
DOI:10.1007/s00330-016-4586-x
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00330-016-4586-x
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Author Notes:A.P. Arnoldi, C.L. Schlett, H. Douis, L.L. Geyer, A.M. Voit, F. Bleisteiner, A.F. Jansson, S. Weckbach

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245 1 0 |a Whole-body MRI in patients with non-bacterial osteitis  |b radiological findings and correlation with clinical data  |c A.P. Arnoldi, C.L. Schlett, H. Douis, L.L. Geyer, A.M. Voit, F. Bleisteiner, A.F. Jansson, S. Weckbach 
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520 |a OBJECTIVES: To correlate clinical findings of Non-bacterial Osteitis (NBO) with whole-body MRI (WB-MRI) findings and determine a radiologic index for NBO (RINBO) which allows standardized reporting of WB-MRI. METHODS AND MATERIALS: In a prospective study, 40 patients with diagnosis of NBO underwent clinical examination and WB-MRI in which STIR- and T1- weighted images were assessed for NBO-typical lesions. Parameters of interest for RINBO were: number of radiologically active lesions (RAL), size of the patients' maximum RAL presence of extramedullary and spinal involvement. Results were tested for statistical agreement of clinical and MR-based lesion detection. RINBO was tested for correlation with clinical activity. RESULTS: 62/95 clinically/radiologically active lesions were found in 30/33 patients. In 45 % of the cohort, more active lesions were detected by WB-MRI than by clinical examination. RINBO was a significant predictor for the presence of clinically active lesions. CONCLUSION: WB-MRI is a powerful diagnostic tool for patients with NBO which can reveal asymptomatic disease activity. With RINBO a standardized evaluation approach is proposed which helps assessing radiologic disease burden and predicts clinical disease activity. KEY POINTS: • Whole body MRI is a powerful diagnostic tool for patients with non-bacterial Osteitis. • Whole body MRI can reveal asymptomatic disease activity. • The radiologic index RINBO offers a standardized evaluation approach. 
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