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Epstein-Barr virus particles induce centrosome amplification and chromosomal instability

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Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increase...

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Auteurs principaux: Shumilov, Anatoliy (Auteur) , Tsai, Ming-Han (Auteur) , Bernhardt, Katharina (Auteur) , Delecluse, Susanne (Auteur) , Mizani, Tuba (Auteur) , Lin, Xiaochen (Auteur) , Jauch, Anna (Auteur) , Kopp-Schneider, Annette (Auteur) , Feederle, Regina (Auteur) , Hoffmann, Ingrid (Auteur) , Delecluse, Henri-Jacques (Auteur)
Format: Article (Journal)
Langue:anglais
Publié: 10 Feb 2017
In: Nature Communications
Year: 2017, Volume: 8
ISSN:2041-1723
DOI:10.1038/ncomms14257
Accès en ligne:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms14257
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/ncomms14257
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Notes sur l'auteur:Anatoliy Shumilov, Ming-Han Tsai, Yvonne T. Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann and Henri-Jacques Delecluse
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Résumé:Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
Description:Gesehen am 08.08.2018
Description matérielle:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms14257

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