CD4+ CD25+ Foxp3+ IFNγ+ CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells
Induced Treg with the phenotype CD4+CD25+Foxp3+IFNc+ were shown to be associated with good longterm graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
Human immunology
Year: 2012, Jahrgang: 74, Heft: 2, Pages: 151-162 |
| ISSN: | 1879-1166 |
| DOI: | 10.1016/j.humimm.2012.09.010 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.humimm.2012.09.010 Verlag, Volltext: http://linkinghub.elsevier.com/retrieve/pii/S0198885912005617 
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| Verfasserangaben: | Volker Daniel, Mahmoud Sadeghi, Haihao Wang, Gerhard Opelz |
| Zusammenfassung: | Induced Treg with the phenotype CD4+CD25+Foxp3+IFNc+ were shown to be associated with good longterm graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute to the inhibition of T-cell activation. |
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| Beschreibung: | Available online 24 September 2012 Gesehen am 09.08.2018 Im Titel sind die Plus-Zeichen "+" hochgestellt |
| Beschreibung: | Online Resource |
| ISSN: | 1879-1166 |
| DOI: | 10.1016/j.humimm.2012.09.010 |