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CD4+ CD25+ Foxp3+ IFNγ+ CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells

Induced Treg with the phenotype CD4+CD25+Foxp3+IFNc+ were shown to be associated with good longterm graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute...

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Bibliographic Details
Main Authors: Daniel, Volker (Author) , Sadeghi, Mahmoud (Author) , Wang, Haihao (Author) , Opelz, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Human immunology
Year: 2012, Volume: 74, Issue: 2, Pages: 151-162
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.010
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.humimm.2012.09.010
Verlag, Volltext: http://linkinghub.elsevier.com/retrieve/pii/S0198885912005617
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Author Notes:Volker Daniel, Mahmoud Sadeghi, Haihao Wang, Gerhard Opelz
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Summary:Induced Treg with the phenotype CD4+CD25+Foxp3+IFNc+ were shown to be associated with good longterm graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute to the inhibition of T-cell activation.
Item Description:Available online 24 September 2012
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Physical Description:Online Resource
ISSN:1879-1166
DOI:10.1016/j.humimm.2012.09.010

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