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Quantitative assessment of radiation dose and fractionation effects on normal tissue by utilizing a novel lung fibrosis index model

Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a critical determinant for late normal tissue complications. While RILF mouse models are frequ...

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Bibliographic Details
Main Authors: Zhou, Cheng (Author) , Moustafa, Mahmoud (Author) , Schwager, Christian (Author) , Bauer, Julia (Author) , Yang, Bing (Author) , Jia, Min (Author) , Mairani, Andrea (Author) , Debus, Jürgen (Author) , Abdollahi, Amir (Author)
Format: Article (Journal)
Language:English
Published: 07 November 2017
In: Radiation oncology
Year: 2017, Volume: 12, Pages: 172
ISSN:1748-717X
DOI:10.1186/s13014-017-0912-y
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13014-017-0912-y
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-017-0912-y
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Author Notes:Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Christian Schwager, Julia Bauer, Bing Yang, Liji Cao, Min Jia, Andrea Mairani, Ming Chen, Longhua Chen, Juergen Debus and Amir Abdollahi
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Summary:Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a critical determinant for late normal tissue complications. While RILF mouse models are frequently approached e.g., as a single high dose thoracic irradiation to investigate lung fibrosis and candidate modulators, a systematic radiobiological characterization of RILF mouse model is urgently needed to compare relative biological effectiveness (RBE) of particle irradiation with protons, helium-, carbon and oxygen ions now available at HIT. We aimed to study the dose-response relationship and fractionation effect of photon irradiation in development of pulmonary fibrosis in C57BL/6 mouse.
Item Description:Gesehen am 09.08.2018
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-017-0912-y

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