Quantitative assessment of radiation dose and fractionation effects on normal tissue by utilizing a novel lung fibrosis index model
Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a critical determinant for late normal tissue complications. While RILF mouse models are frequ...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 November 2017
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| In: |
Radiation oncology
Year: 2017, Volume: 12, Pages: 172 |
| ISSN: | 1748-717X |
| DOI: | 10.1186/s13014-017-0912-y |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13014-017-0912-y Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-017-0912-y 
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| Author Notes: | Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Christian Schwager, Julia Bauer, Bing Yang, Liji Cao, Min Jia, Andrea Mairani, Ming Chen, Longhua Chen, Juergen Debus and Amir Abdollahi |
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| 520 | |a Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a critical determinant for late normal tissue complications. While RILF mouse models are frequently approached e.g., as a single high dose thoracic irradiation to investigate lung fibrosis and candidate modulators, a systematic radiobiological characterization of RILF mouse model is urgently needed to compare relative biological effectiveness (RBE) of particle irradiation with protons, helium-, carbon and oxygen ions now available at HIT. We aimed to study the dose-response relationship and fractionation effect of photon irradiation in development of pulmonary fibrosis in C57BL/6 mouse. | ||
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