New anticoagulants - promising and failed developments
New direct and indirect acting factor Xa (FXa) and thrombin inhibitors are being developed to overcome the downsides of the conventional anticoagulants - unfractionated and low molecular weight heparins and vitamin K antagonists. Ximelagatran and idraparinux failed to demonstrate an acceptable safet...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
British journal of pharmacology
Year: 2011, Volume: 165, Issue: 2, Pages: 363-372 |
| ISSN: | 1476-5381 |
| DOI: | 10.1111/j.1476-5381.2011.01578.x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/j.1476-5381.2011.01578.x Verlag, Volltext: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2011.01578.x 
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| Author Notes: | Job Harenberg, Svetlana Marx, Martin Krejczy and Martin Wehling |
| Summary: | New direct and indirect acting factor Xa (FXa) and thrombin inhibitors are being developed to overcome the downsides of the conventional anticoagulants - unfractionated and low molecular weight heparins and vitamin K antagonists. Ximelagatran and idraparinux failed to demonstrate an acceptable safety profile. Rivaroxaban and dabigatran are approved for the post-operative prevention of thromboembolic complications after elective hip or knee replacement surgery; dabigatran is approved for the prevention of embolism in patients with atrial fibrillation in an increasing number of countries. Several novel indirect antithrombin-dependent anticoagulants as well as antithrombin-independent oral direct FXa and thrombin inhibitors are investigated in multiple indications for the prophylaxis and treatment of venous thromboembolism and the prophylaxis of arterial thrombotic disorders. Quality-adjusted life years costs and incremental cost-effectiveness ratios are relatively high at present, but may decrease after approval of more new anticoagulants for additional indications. |
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| Item Description: | First published: 08 July 2011 Gesehen am 09.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1476-5381 |
| DOI: | 10.1111/j.1476-5381.2011.01578.x |