Circulating microparticles in patients with benign and malignant ovarian tumors
Background: Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. Patients and Methods: Microparticles from platelets/megakaryocytes, activated platelets and endothelial...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Anticancer research
Year: 2012, Volume: 32, Issue: 5, Pages: 2009-2014 |
| ISSN: | 1791-7530 |
| Online Access: | Verlag, kostenfrei, Volltext: http://ar.iiarjournals.org/content/32/5/2009
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| Author Notes: | A. Rank, S. Liebhardt, J. Zwirner, A. Burges, R. Nieuwland and B. Toth |
| Summary: | Background: Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. Patients and Methods: Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor exposing microparticles and D-dimer values were examined in patients with newly diagnosed ovarian lesions before surgery, and were correlated with tumor histology. Results: Higher counts of CD63-positive microparticles were detected in patients with ovarian cancer [mean=276×106 (range: 64-948)/l; n=12] as compared to patients with benign ovarian tumors [146×106 (45-390)/l; n=21; p=0.014]. D-dimer values were also increased in patients with cancer [860 (180-4500) ng/l versus 280 (170-2720) ng/l; p=0.001]. Conclusion: Elevated levels of CD63-positive microparticles and D-dimer reflect the procoagulant phenotype of these patients. However, for the discrimination between benign and malignant ovarian tumors, measuring preoperative levels of microparticles does not seem to be helpful. |
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| Item Description: | Keine DOI vorhanden Gesehen am 09.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |