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Intraindividual xomparison of 18F-PSMA-1007 PET/CT, multiparametric MRI, and radical prostatectomy specimens in patients with primary prostate cancer: a retrospective, proof-of-concept study

68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of 68Ga the development of alternative tracers is of high interest. The ob...

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Hauptverfasser: Kesch, Claudia (VerfasserIn) , Vinsensia, Maria (VerfasserIn) , Radtke, Jan Philipp (VerfasserIn) , Schlemmer, Heinz-Peter (VerfasserIn) , Heller, Martina (VerfasserIn) , Ellert, Elena (VerfasserIn) , Holland-Letz, Tim (VerfasserIn) , Duensing, Stefan (VerfasserIn) , Grabe, Niels (VerfasserIn) , Afshar-Oromieh, Ali (VerfasserIn) , Wieczorek, Kathrin (VerfasserIn) , Kiß, Oliver (VerfasserIn) , Cardinale, Jens (VerfasserIn) , Kratochwil, Clemens (VerfasserIn) , Hohenfellner, Markus (VerfasserIn) , Kopka, Klaus (VerfasserIn) , Haberkorn, Uwe (VerfasserIn) , Hadaschik, Boris (VerfasserIn) , Giesel, Frederik L. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 4, 2017
In: Journal of nuclear medicine
Year: 2017, Jahrgang: 58, Heft: 11, Pages: 1805-1810
ISSN:2159-662X
DOI:10.2967/jnumed.116.189233
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.2967/jnumed.116.189233
Verlag, kostenfrei, Volltext: http://jnm.snmjournals.org/content/58/11/1805
Volltext
Verfasserangaben:Claudia Kesch, Maria Vinsensia, Jan P. Radtke, Heinz P. Schlemmer, Martina Heller, Elena Ellert, Tim Holland-Letz, Stefan Duensing, Nils Grabe, Ali Afshar-Oromieh, Kathrin Wieczorek, Martin Schäfer, Oliver C. Neels, Jens Cardinale, Clemens Kratochwil, Markus Hohenfellner, Klaus Kopka, Uwe Haberkorn, Boris A. Hadaschik, Frederik L. Giesel
Beschreibung
Zusammenfassung:68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of 68Ga the development of alternative tracers is of high interest. The objective of this study was to examine the value of the new PET tracer 18F-PSMA-1007 for the staging of local disease by comparing it with multiparametric MRI (mpMRI) and radical prostatectomy (RP) histopathology. Methods: In 2016, 18F-PSMA-1007 PET/CT was performed in 10 men with biopsy-confirmed high-risk PCa. Nine patients underwent mpMRI in the process of primary diagnosis. Consecutively, RP was performed in all 10 men. Agreement analysis was performed retrospectively. PSMA staining was added for representative sections in RP specimen slices. Localization and agreement analysis of 18F-PSMA-1007 PET/CT, mpMRI, and RP specimens was performed by dividing the prostate into 38 sections as described in the prostate imaging reporting and data system (PI-RADS) (version 2). Sensitivity, specificity, positive predictive values, negative predictive values (NPVs), and accuracy were calculated for total and near-total agreement. Results: 18F-PSMA-1007 PET/CT had an NPV of 68% and an accuracy of 75%, and mpMRI had an NPV of 88% and an accuracy of 73% for total agreement. Near-total agreement analysis resulted in an NPV of 91% and an accuracy of 93% for 18F-PSMA-1007 PET/CT and 91% and 87% for mpMRI, respectively. Retrospective combination of mpMRI and PET/CT had an accuracy of 81% for total and 93% for near-total agreement. Conclusion: Comparison with RP histopathology demonstrates that 18F-PSMA-1007 PET/CT is promising for accurate local staging of PCa.
Beschreibung:Im Titel ist die Zahl 18 als Hochzahl dargestellt
Gesehen am 13.08.2018
Beschreibung:Online Resource
ISSN:2159-662X
DOI:10.2967/jnumed.116.189233

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