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Communicate or die: a model for HPV+ and HPV− CSCs and their interactions with SDF-1α

Background/Aim: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1 alpha (SDF-1 alpha) plays a critical role in the communication between CSCs and their microenvironment. We investigated the inf...

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Bibliographische Detailangaben
Hauptverfasser: Jungbauer, Frederic (VerfasserIn) , Aderhold, Marc Christoph (VerfasserIn) , Birk, Richard (VerfasserIn) , Hörmann, Karl (VerfasserIn) , Kramer, Benedikt (VerfasserIn) , Walter, Beatrice (VerfasserIn) , Thorn, Carsten Volker (VerfasserIn) , Lammert, Anne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2017
In: Anticancer research
Year: 2017, Jahrgang: 37, Heft: 9, Pages: 4827-4836
ISSN:1791-7530
DOI:10.21873/anticanres.11890
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.11890
Verlag, Volltext: http://ar.iiarjournals.org/content/37/9/4827.abstract
Volltext
Verfasserangaben:Frederic Jungbauer, Christoph Aderhold, Richard Birk, Karl Hoermann, Benedikt Kramer, Beatrice Kuhlin, Carsten Thorn, Claudia Umbreit and Anne Lammert
Beschreibung
Zusammenfassung:Background/Aim: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1 alpha (SDF-1 alpha) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1 alpha on HPV+/HPV-SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs. Materials and Methods: We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1 alpha on proliferation, morphology and migration of HPV+/HPV- SCCs. Results: HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1 alpha. HPV+ SCCs rested nearly unaffected by SDF-1 alpha. Conclusion: Weakened reaction to SDF-1 alpha in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents.
Beschreibung:Gesehen am 13.08.2018
Beschreibung:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.11890

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