Communicate or die: a model for HPV+ and HPV− CSCs and their interactions with SDF-1α
Background/Aim: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1 alpha (SDF-1 alpha) plays a critical role in the communication between CSCs and their microenvironment. We investigated the inf...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Anticancer research
Year: 2017, Jahrgang: 37, Heft: 9, Pages: 4827-4836 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.11890 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.11890 Verlag, Volltext: http://ar.iiarjournals.org/content/37/9/4827.abstract 
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| Verfasserangaben: | Frederic Jungbauer, Christoph Aderhold, Richard Birk, Karl Hoermann, Benedikt Kramer, Beatrice Kuhlin, Carsten Thorn, Claudia Umbreit and Anne Lammert |
MARC
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| 245 | 1 | 0 | |a Communicate or die |b a model for HPV+ and HPV− CSCs and their interactions with SDF-1α |c Frederic Jungbauer, Christoph Aderhold, Richard Birk, Karl Hoermann, Benedikt Kramer, Beatrice Kuhlin, Carsten Thorn, Claudia Umbreit and Anne Lammert |
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| 520 | |a Background/Aim: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1 alpha (SDF-1 alpha) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1 alpha on HPV+/HPV-SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs. Materials and Methods: We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1 alpha on proliferation, morphology and migration of HPV+/HPV- SCCs. Results: HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1 alpha. HPV+ SCCs rested nearly unaffected by SDF-1 alpha. Conclusion: Weakened reaction to SDF-1 alpha in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents. | ||
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