Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. More...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 July 2012
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| In: |
Nature neuroscience
Year: 2012, Jahrgang: 15, Heft: 8, Pages: 1111-1113 |
| ISSN: | 1546-1726 |
| DOI: | 10.1038/nn.3151 |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1038/nn.3151 Verlag, Volltext: https://www.nature.com/articles/nn.3151 
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| Verfasserangaben: | Ana M.M. Oliveira, Thekla J. Hemstedt & Hilmar Bading |
| Zusammenfassung: | Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice. |
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| Beschreibung: | Die Datei enthält zwei zusätzliche Seiten mit einer Beschreibung der Online-Methoden Gesehen am 14.08.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-1726 |
| DOI: | 10.1038/nn.3151 |