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Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa

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<b><i>Objective:</i></b> The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (<i>FTO</i>) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology o...

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Bibliographic Details
Main Authors: Müller, Timo Dirk (Author) , Greene, Brandon (Author) , Herzog, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: June 27, 2012
In: Obesity facts
Year: 2012, Volume: 5, Issue: 3, Pages: 408-419
ISSN:1662-4033
DOI:10.1159/000340057
Online Access:Verlag, Volltext: http://dx.doi.org/10.1159/000340057
Verlag, Volltext: https://www.karger.com/Article/FullText/340057
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Author Notes:Timo D. Müller, Brandon H. Greene, Laura Bellodi, Maria C. Cavallini, Elena Cellini, Daniela Di Bella, Stefan Ehrlich, Stefano Erzegovesi, Xavier Estivill, Fernando Fernández-Aranda, Manfred Fichter, Christian Fleischhaker, Susann Scherag, Monica Gratacòs, Harald Grallert, Beate Herpertz-Dahlmann, Wolfgang Herzog, Thomas Illig, Ulrike Lehmkuhl, Benedetta Nacmias, Marta Ribasés, Valdo Ricca, Helmut Schäfer, André Scherag, Sandro Sorbi, Heinz-Erich Wichmann, Johannes Hebebrand, Anke Hinney
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Summary:<b><i>Objective:</i></b> The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (<i>FTO</i>) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). <b><i>Methods:</i></b> Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. <b><i>Results:</i></b> In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001-∞; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932-∞; one-sided p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027-1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101-2.541, two-sided p = 0.015,). <b><i>Conclusion:</i></b> Our data suggest that the obesity-predisposing <i>FTO</i> allele might be relevant in both AN and BN.
Item Description:Published online: June 27, 2012
Gesehen am 15.08.2018
Physical Description:Online Resource
ISSN:1662-4033
DOI:10.1159/000340057

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