Physiological functions of APP family proteins
Biochemical and genetic evidence establishes a central role of the amyloid precursor protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically,...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Cold Spring Harbor perspectives in medicine
Year: 2011, Volume: 2, Issue: 2, Pages: 1-18 |
| ISSN: | 2157-1422 |
| DOI: | 10.1101/cshperspect.a006288 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1101/cshperspect.a006288 Verlag, kostenfrei, Volltext: http://perspectivesinmedicine.cshlp.org/content/2/2/a006288 
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| Author Notes: | Ulrike C. Müller, and Hui Zheng |
| Summary: | Biochemical and genetic evidence establishes a central role of the amyloid precursor protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy. As such, the biological functions of APP and its processing products have been the subject of intense investigation, and the past 20+ years of research have met with both excitement and challenges. This article will review the current understanding of the physiological functions of APP in the context of APP family members. |
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| Item Description: | Published in Advance December 6, 2011 Gesehen am 18.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2157-1422 |
| DOI: | 10.1101/cshperspect.a006288 |